The Supreme Court will dive headfirst into the politically fraught issue of transgender rights on Wednesday when it hears a challenge to Tennessee’s ban on gender-affirming care for minors in the highest-profile case of the fall.

WASHINGTON — The Supreme Court hears oral arguments Wednesday in a dispute over a Tennessee ban on certain medical treatments for transgender children, in a case that could set the boundaries on gender identity policies for states and Congress.

The Supreme Court will consider if states can keep transgender adolescents from puberty blockers and hormone therapy, a major culture war flashpoint.