Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 31 (Aug. 5, 2008), pp. 10750-10755 (6 pages) The discovery of ghrelin O-acyltransferase (GOAT) opens the ...

GOAT activates ghrelin by acylation, attaching a fatty acid. To block this acylation and thus ghrelin signaling, we designed GO-CoA-Tat, a "bisubstrate" compound that incorporates both ghrelin and an ...

In a prospective trial with 412 HD patients, CVD incidence was recorded over the course of three years (Intern Med 2010;49:2057-2064). Stratifying groups by low and high acyl ghrelin levels, acylated ...

Ghrelin is a hormone. Its primary role is to regulate appetite. It also facilitates the function of the pituitary gland, controls insulin, and protects cardiovascular health. In this article, we ...

CINCINNATI—New research led by the University of Cincinnati (UC) suggests that the hunger hormone ghrelin is activated by fats from the foods we eat—not those made in the body—in order to optimize ...

Ghrelin is a recently identified growth hormone (GH) secretogogue whose administration not only induces GH release but also stimulates food intake, increases adiposity, and reduces fat utilization in ...

Working out hard may fast-track your weight loss goals — especially if you’re a woman. A small study from the University of Virginia found that vigorous exercise suppresses levels of the “hunger ...

Higher levels of the stomach-derived hormone ghrelin, which stimulates appetite, predict a greater preference for smaller immediate monetary rewards over larger delayed financial rewards, a new study ...

A randomized multicenter phase II trial on efficacy of high-slip skin care pad for hand-foot skin reaction caused by sorafenib in patients with renal cell carcinoma. Background: CC is a frequent and ...