Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a ...
Investigators may have uncovered the general mechanism that governs RNA polymerase movement, they report in the January 28 issue of Cell. The finding "provides a framework for understanding how ...
The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's ...
RNA plays a vital role in how our genes are expressed and how diseases develop. Yet, because RNA molecules constantly change ...
A newly developed mouse model enables real-time visualization of RNA Polymerase II (RNAP2) during DNA transcription, as ...
A recent study in Nature Communications examined how RNA polymerase I (Pol I) responds to abasic (Ap) site formation—the most common type of DNA damage. The researchers found that Pol I helps maintain ...
In the Herman Lab, we set out to exploit the speed and power of bacterial genetics to understand the interactions between transcription, core transcription factors, and genome maintenance.