Leptin is an adipose tissue hormone that regulates energy and metabolic balance by activating the leptin receptor (LEPR). An imbalance in leptin or LEPR signalling — whether through hyperleptinemia or ...

A brain circuit involving leptin allows mice to carry out vital behaviors, such as eating and sleeping, during anxious episodes. A study led by researchers at the University of Cologne and University ...

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss. Worldwide obesity rates have ...

Obesity has become a global epidemic, and the need for treatment and monitoring for people with obesity is growing.

A study more closely links obesity to dementia, finding that leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged ...

How do mammals manage to eat in situations that cause anxiety, step into exposed spaces, or slow down when anxiety drives them to keep moving? A new study pinpoints a leptin-sensitive circuit in the ...

Conversations between neighbors in the biology department at the University of Akron have spawned a broader evolutionary view of leptin, the hormone that periodically makes headlines as a potential ...