Lipodystrophy syndromes (LDs) are characterized by loss of adipose tissue, metabolic complications such as dyslipidemia, insulin resistance, and fatty liver disease, as well as accelerated ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) poses a significant challenge in modern medicine due to its high prevalence. The pathogenesis of MAFLD involves a complex dysmetabolic ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...

Leptin is a hormone that makes you feel full. Leptin was only discovered in 1994, and scientists are still working to ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...

For more than a hundred years, insulin has been the key to controlling type 1 diabetes. It has saved lives by preventing diabetic ketoacidosis (DKA), a life-threatening condition that happens when the ...

Researchers have successfully treated two unrelated children with characteristics of leptin dysfunction — including intense hyperphagia, impaired satiety, and severe, early onset obesity — only after ...

A paper published in the May issue of Diabetes implicates triglycerides in the mechanism of leptin resistance. These fats, elevated in obesity, are what disrupt the transport of the hormone across the ...

Your body relies on a complex network of glands, hormones and internal feedback loops to keep your weight in check. This weight-management system usually works on autopilot as you go about your day.