DNA damage, caused by radiation and a variety of chemical agents, can lead to mutations, genomic instability, cancer and cell death. Genetic studies in the yeast Saccharomyces cerevisiae have revealed ...

Protein ubiquitylation is now recognized as a major post-translational modification in eukaryotes. Either a single ubiquitin moiety or a ubiquitin chain can be conjugated to the target protein at a ...

A recent study published in the Cell Chemical Biology Journal described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells. PCNA is a conserved ...

Epidermal Growth Factor Receptor (EGFr) status detection in correlation to objective response on cetuximab-based therapy in patients (pts) with advanced colorectal cancer (ACC) No significant ...

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, today published a new study explaining how they took a protein once thought to be too ...

"Our cancer-killing pill is like a snowstorm that closes a key airline hub, shutting down all flights in and out only in planes carrying cancer cells," says the professor who has been developing the ...