DREAM complex acts as master brake on DNA repair, where higher activity steadily increases mutations and accelerates aging.

During development, many crucial genes help organisms form properly. One of those genes is myogenic determination gene number 1 (MyoD), which can exert a powerful influence as a “genome organizer." It ...

A high throughput screen of >30,000 diverse repressor domains from across the tree of life identifies repressor domains with unique structures that underpin enhanced epigenetic effector domain potency ...

The phytohormone abscisic acid (ABA) modulates the expression of many genes important to plant growth and development and to stress adaptation. In this study, we found that an APETALA2/EREBP-type ...

A protein known to repress gene transcription at the molecular level in a variety of processes also blocks embryonic neural stem cells from differentiating into neurons, according to a new study. A ...

Plant inflorescence meristems and floral meristems possess specific boundary domains that result in proper floral organ separation and specification. HANABA TARANU (HAN) encodes a boundary-expressed ...

Researchers have developed two types of programmable repressor elements that can switch off the production of an output protein in synthetic biology circuits by up to 300-fold in response to almost ...

Crystal structures of the Lac repressor, with and without isopropylthiogalactoside (IPTG), and the repressor bound to operator have provided a model for how the binding of the inducer reduces the ...

A first-in-human, open-label, phase I trial of daily oral PCLX-001, an NMT inhibitor, in patients with relapsed/refractory B-cell lymphomas and advanced solid tumors. This is an ASCO Meeting Abstract ...

Tomato fruit ripening is a tightly regulated process involving hormonal signaling, metabolic reprogramming, and epigenetic modulation. Ethylene plays a pivotal role in climacteric fruit ripening, but ...

Anthony Bellanger, general secretary of the International Federation of Journalists, told VOA that Iran is "a repressor of press freedom," and he urged foreign journalists to be " as cautious as ...