MIT and Harvard scientists have created engineered CAR-NK cells that can hide from the immune system and more effectively destroy cancer. The cells are designed to suppress immune-rejection signals and enhance tumor-killing power.

Living with an autoimmune disease often means navigating a lifelong, complex condition. A recent study estimates that autoimmune diseases affect 400 to 600 million people worldwide, with the burden continuing to grow.

Amyotrophic lateral sclerosis may involve an autoimmune component — a finding that could reshape treatment strategies and lead to new tools for predicting disease course.

In experiments with mouse models of breast, pancreatic, and muscle cancers, researchers at Johns Hopkins All Children’s Hospital report new evidence that a novel means of boosting the natural immune system prevents cancer recurrence and improves survival.

The cell nucleus goes a long way during an immune response, both literally and figuratively. New research published in Science Immunology shows that in some white blood cells, this genetic storage facility can travel across the entire length of the cell to help clear out infections, a completely unexpected role for the cell's largest organelle.

Hodgkin lymphoma and other malignancies that express the CD30 protein have been the scourge of oncologists for decades. For patients whose cancer returns or is treatment-refractory, choices are minimal and temporary.

CAR-T cell therapy has cured some children with blood cancers and is being studied in solid tumors, where responses differ due to how these cancers grow.

Researchers at the University of Granada and Mount Sinai Hospital in New York have developed a luminescent probe, called GLed, capable of measuring the activity of the immune system in real time and with unprecedented accuracy.