Obesity: Researchers discover a cause of leptin resistance -- and how to reverse it. ScienceDaily . Retrieved June 11, 2025 from www.sciencedaily.com / releases / 2025 / 03 / 250304113650.htm ...

"Before our research, the cause of obesity in diet-induced obese mice was unknown, leaving a critical gap in our ...

That’s called leptin resistance. Doctors don’t test for it regularly, but experts agree it’s common in people with obesity. Think of leptin resistance like insulin resistance in type 2 diabetes.

Leptin resistance in obesity. Leptin interacts with specific leptin receptors to inhibit excess feeding and its elevation and obesity is therefore often thought to indicate a leptin resistant state.

In most people the function of leptin is to decrease appetite and increase energy expenditure, helping you maintain a healthy ...

Obesity, Leptin Resistance, and Metabolic Syndrome MS, defined by a constellation of high blood pressure, elevated triglycerides, insulin resistance, and abdominal obesity, is a major risk factor ...

Defects in POMC-expressing neurons are also known to cause leptin resistance and obesity, Friedman notes, adding, “it was satisfying to find that an acquired form of leptin resistance targets this ...

That’s called leptin resistance. Doctors don’t test for it regularly, but experts agree it’s common in people with obesity. Think of leptin resistance like insulin resistance in type 2 diabetes.

Anil Oza is STAT’s 2024-2025 Sharon Begley Science Reporting Fellow. You can reach Anil on Signal at aniloza.16. The hormone leptin was discovered 30 years ago to much fanfare. Scientists hoped ...

Researchers discover a cause of leptin resistance—and how to reverse it . Rockefeller University. Journal Cell Metabolism DOI 10.1016/j.cmet.2025.01.001 ...

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category. Though a complex interplay of genes, diet, and environment contribute, 90% of ...