Researchers from the Vanderbilt University School of Medicine Basic Sciences have uncovered the first example of activity-dependent development of hypothalamic neural circuitry. Although previous ...

Researchers have successfully treated two unrelated children with characteristics of leptin dysfunction — including intense hyperphagia, impaired satiety, and severe, early onset obesity — only after ...

Researchers from the lab of Richard Simerly have uncovered the first example of activity-dependent development of hypothalamic neural circuitry. The work also suggests a novel role for the hunger ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) poses a significant challenge in modern medicine due to its high prevalence. The pathogenesis of MAFLD involves a complex dysmetabolic ...

Phase I dose escalation study of pan-histone deacetylase (HDAC) inhibitor abexinostat in combination with cisplatin in patients with advanced non-keratinizing nasopharyngeal carcinoma. E1308: ...

Annals of Nutrition & Metabolism, Vol. 75, No. 3 (2019), p. 197 (1 page) Liang J, Lan J, Li M, Wang F. Associations of Leptin Receptor and Peroxisome Proliferator-Activated Receptor Gamma ...

“Up until now, the scientific community thought that leptin acts exclusively in neurons to modulate behavior and body weight,” Horvath said in a press release. “This work is now changing that paradigm ...

Obesity and cancer are two major health challenges of our time, yet the link between them remains only partially understood. New research now highlights a molecular chain of events in estrogen ...

Axons from AgRP neurons, in red, innervate oxytocin neurons, in green, in the PVH. Neuronal activity of AgRP neurons is required for normal targeting of their axons to oxytocin neurons, as well as for ...