The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock Purdy. Backup quarterback Brandon

After that, there is no significant NFL talent on the 49ers roster, while the edges are equally deficient in both depth and run-stopping abilities. For that reason, the Bills may pursue interior runs early and often while San Francisco struggles to find ...

The National Weather Service has extended its "lake effect snow warning" in Buffalo through Monday at 7 p.m. ET, with potentially 2-3 feet of additional

They don't get a divisional opponent in Week 13, but a struggling San Francisco 49ers team still possesses plenty of firepower for Buffalo to be concerned with as it starts December. Here are five keys to victory for the Bills as they welcome the 49ers into Orchard Park,

The San Francisco 49ers and Buffalo Bills are set to face-off in the Week 13 edition of Sunday Night Football. Before the season began, this matchup was circled

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

Dive into the San Francisco 49ers vs. Buffalo Bills showdown with a look at odds, predictions, and the best betting options.

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got destroyed by the Green Bay Packers. Granted Brock Purdy didn't play, but the 49ers didn't look like an NFC contender.

Coming into the 2024 NFL season, it wouldn't have been out of the ordinary to find a Super Bowl prediction featuring the Buffalo Bills or San Francisco 49ers, or both. Josh Allen's AFC squad entered looking for its sixth straight playoff appearance.

You can listen on SiriusXM satellite radio on channel 225 (Bills feed) and channel 226 (49ers feed), and on traditional radio, the Bills Radio Network has stations all across the state. Chris Brown has the play-by-play, Eric Wood is the analyst, and Sal Capaccio is the sideline reporter. The network includes:

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.