San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

The 49ers lost their third straight game on Sunday to fall to 5-7 as the team's remarkably disappointing season continues.

The 24-year-old Guerendo was a fourth-round pick in the 2024 NFL draft. He transferred to Louisville for the 2023 season ...

It’s been a rough day – and a rough season - for 49ers fans. Many are depressed over a brutal loss Monday night in Buffalo ...

San Francisco 49ers star running back Christian McCaffrey will not need surgery on his injured right knee but he will miss the rest of the regular season.

Replacing McCaffrey won't be easy for fantasy football managers, but these three running backs present the most viable ...

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian McCaffery and Deebo Samuel?

McCaffrey suffered a potentially season-ending PCL injury, 49ers coach Kyle Shanahan said after the 35-10 loss to the Bills.

Back-to-back blowout losses and another injury to star back Christian McCaffrey might just be the final blow to the dwindling ...

Whereas New York Jets fans have little to celebrate, their rival fans in the AFC East might be celebrating a little too much.