San Francisco 49ers running back Isaac Guerendo was carted off the field in the first quarter against the Arizona Cardinals.

GLENDALE -- San Francisco 49ers RB Isaac Guerendo was carted off the field in Week 18's matchup against the Arizona Cardinals. He has already been ruled out with a knee and ankle injury. On just the ...

Behind 242 passing yards and four touchdowns from quarterback Kyler Murray, the Cardinals rolled to a victory over the 49ers in both teams' season finale.