Leptin is a hormone that helps signal to your brain when you're satiated or hungry. However, leptin resistance may block this signal and increase your risk of obesity. Learn more about leptin and ...

Defining Leptin Resistance . Once fat tissue secretes leptin and ghrelin (another appetite-suppressing hormone), they enter ...

Leptin resistance can lead to overeating and excess fat storage. Other health problems can mess with your leptin signaling too. For example, chronic inflammation and high levels of triglycerides ...

Researchers discover a cause of leptin resistance—and how to reverse it . Rockefeller University. Journal Cell Metabolism DOI 10.1016/j.cmet.2025.01.001 ...

That’s called leptin resistance. Doctors don’t test for it regularly, but experts agree it’s common in people with obesity. Think of leptin resistance like insulin resistance in type 2 diabetes.

Defects in POMC-expressing neurons are also known to cause leptin resistance and obesity, Friedman notes, adding, “it was satisfying to find that an acquired form of leptin resistance targets this ...

Leptin resistance occurs when there’s plenty of the hormone available but its signal is impaired. Therefore, increased leptin levels are not what’s important for weight loss, ...

Leptin resistance is a condition in which the brain does not respond to leptin as it should. Scientists are still learning ...

Obesity: Researchers discover a cause of leptin resistance -- and how to reverse it Date: March 4, 2025 Source: Rockefeller University Summary: Most obese patients grow resistant to satiety ...