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When the scale refuses to budge despite your best efforts at diet and exercise, the answer might lie deeper than calories in ...

Medically reviewed by Kelly Wood, MD Hormones play a major role in energy usage and storage, metabolism, growth, and fat distribution. When hormone levels shift, unexpected weight gain may occur.

Iran’s “Axis of Resistance,” the network of militias it has fostered in the Middle East to help it fight Israel, has become seriously degraded, experts say. By Christina Goldbaum For four ...

Data suggest that as weight is gained and leptin levels continually rise, the brain gradually stops responding to leptin. “This phenomenon is analogous to insulin resistance, which is the most common ...

But now Bowen Tan, Kristina Hedbacker, and other researchers in Friedman’s Laboratory of Molecular Genetics have discovered a neural mechanism involved in leptin resistance—and, crucially, a ...

Obesity: Researchers discover a cause of leptin resistance -- and how to reverse it Date: March 4, 2025 Source: Rockefeller University Summary: Most obese patients grow resistant to satiety ...

Leptin-sensitive animals showed no such dysregulation. “With this as a starting point, we found that mTOR is hyperactive in specific brain regions and cell types in obese animals,” Tan said.