The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

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Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

The San Francisco 49ers have struggled to get Deebo Samuel going, and one NFL analyst thinks they may not be able to.

San Francisco 49ers running back Christian McCaffrey reflected on his 2024 NFL season that fell short of expectations with a ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

A spate of injuries has derailed the 49ers' Super Bowl hopes his season, but the bigger question is if their title window has ...

What has to be done for the San Francisco 49ers to have a chance at the playoffs or at the very least, a winning season in ...

McCaffrey should be fine long term, though it's hard to say whether he'd be able to play again this season if the 49ers made ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

The San Francisco 49ers could say goodbye to RB Jordan Mason, one of their most productive offensive players, in the near ...