A disappointing 2024 saw the San Francisco 49ers miss the postseason and register a 6-11 regular season mark. Injuries to key players and positions contributed to much of that failure, and the team hopes to remain healthy in 2025. The biggest concern is star running back Christian McCaffrey, who missed much of last year with a number of ailments.

The San Francisco 49ers went into the past few training camps with one of the NFL's deepest rosters filled with established stars that left little opportunity for rookies to contribute. That's far from the case this year as San Francisco underwent a roster reset in the offseason that has infused the team with more youth and the most opportunities for rookies to compete since 2019 when draft picks like Nick Bosa,

We dive into the San Francisco 49ers' 2025 NFL odds, review their offseason and preview their season from a betting perspective

“One prominent name that surfaces inside this ideology is Texas quarterback Arch Manning, who some believe will end up being the No. 1 pick in the 2026 NFL Draft following his 2025 season — if he actually chooses to leave college before his senior year in 2026.”

I think it’s cool that everybody’s watching and it puts that added pressure on,” San Francisco’s special teams coach said.

The 49ers need someone who can be an NFL starter at wide receiver. That person is 6-time Pro Bowler Keenan Allen, who is still a free agent