Not interested in this game? Check out expert picks and best bets for every NFL game this week. Buffalo had its bye and the 49ers are so banged up that it’s tough to back them in this spot — especially cause the Bills are hitting their stride.

It’s Week 13 in the NFL, and the Buffalo Bills are preparing to host the San Francisco 49ers on Sunday Night Football at 8:20 p.m. Buffalo (9-2) enters the contest having won six straight and is coming off a bye week. Meanwhile, San Francisco (5-6) has dropped two straight and three of five as injuries continue to pile up.

Bills' QB Josh Allen is the current favorite for MVP. Expectations aren't something I like to make a habit. However, it's hard not to expect the best from Allen and the Bills this week. Beating the Chiefs the way they did helped them check off that confidence box, and they did it on their 12th straight week of football.

Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

The Bills can clinch the division in Week 13 if the Miami Dolphins lose to the Green Bay Packers at Lambeau Field on Thursday Night Football and Buffalo defeats the San Francisco 49ers at Highmark Stadium on Sunday Night Football. Kickoff for both games is set for 8:20 p.m.

The Buffalo Bills will now continue their 2024 season in a well-rested fashion. In Week 13, the Bills (9-2) host the