The San Francisco 49ers on Wednesday continued adjusting to life without running backs Christian McCaffrey and Jordan Mason.

Slow motion video shows where 49ers running back Christian McCaffrey seemingly injured himself and ended his season.

The San Francisco 49ers return to Levi's Stadium to face the Chicago Bears. This matchup marks the 70th all-time meeting ...

The San Francisco 49ers officially placed Christian McCaffrey on Injured Reserve on Tuesday. McCaffrey's 2024 season is done ...

After burying the San Francisco 49ers in a snow game Sunday, in which running back Christian McCaffrey left with a ...

Buffalo Bills fans are doing it again. After burying the 49ers in a snow game on Sunday night, in which Christian McCaffrey ...

The San Francisco 49ers could say goodbye to RB Jordan Mason, one of their most productive offensive players, in the near ...

The San Francisco 49ers are moving forward without star running back Christian McCaffrey or backup Jordan Mason for the ...

The San Francisco 49ers are falling behind the Seattle Seahawks in the NFC West. Losers of three consecutive contests, it was ...

49ers head coach Kyle Shanahan told reporters Monday that McCaffrey suffered a posterior cruciate ligament (PCL) injury ...

A spate of injuries has derailed the 49ers' Super Bowl hopes his season, but the bigger question is if their title window has ...

Rookie fourth-round pick Isaac Guerendo seemed to be an afterthought in the San Francisco 49ers backfield with Christian ...