SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a process known as serotonin reuptake.

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SERT is found in various locations throughout the body, each contributing to different aspects of serotonin regulation. In the brain, SERT is present on serotonergic neurons, where it regulates …

Abstract The serotonin transporter (SERT) belongs to the monoamine transporter family, which also includes the dopamine and norepinephrine transporters. SERT is essential for regulating …

Jan 10, 2024 · The presynaptic serotonin transporter (SERT) clears extracellular serotonin following vesicular release to ensure temporal and spatial regulation of serotonergic signalling …

Dec 1, 2021 · The serotonin transporter (SERT) terminates serotonin signaling by using sodium and chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target …

Feb 14, 2025 · What is the Serotonin Transporter (SERT)? The serotonin transporter (SERT), also known as SLC6A4, is a protein found in the membrane of presynaptic neurons. It is …

The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire serotoninergic system and its receptors via modulation of extracellular fluid serotonin …

The serotonin transporter (SERT) terminates serotonergic signaling and enables refilling of synaptic vesicles by mediating reuptake of serotonin (5-HT) released into the synaptic cleft.